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Dr Yung-Yi Chen
Characterization and Optimization of a Novel VEGFR-2 Receptor Antagonist
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Angiogenesis, the process of new blood vessel growth, is vital throughout life for the growth and development of new body tissues and the healing of existing ones. When this repair process fails tissues die due to lack of oxygen, as occurs in heart disease. However inappropriate angiogenesis can also be detrimental and contributes to a variety of diseases including cancer, rheumatoid arthritis and loss of vision in old age (age related macular degeneration).
We have identified a small part of a protein, which occurs naturally in the body that inhibits angiogenesis and tumour growth in the lab, and offers several advantages over existing treatments. Moreover it could potentially be converted into a molecule that stimulates angiogenesis, which would be of benefit in treating heart disease. The aim of this project is to further characterize and refine this molecule so that it may be used therapeutically in humans.
More info: This project has now finished, for more information please Download the Executive Summary
